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Record #54981

MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex

M Konopleva, M Milella, P Ruvolo, J C Watts, M R Ricciardi, B Korchin, T McQueen, W Bornmann, T Tsao, P Bergamo, D H Mak, W Chen, J McCubrey, A Tafuri, M Andreeff

Journal

Publisher

Springer - Nature Publishing Group

Original paper date

Nov 8, 2011

Original DOI

10.1038/leu.2011.287

Country

🇮🇹 Italy · 🇺🇸 United States

Institution

Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA · Division of Medical Oncology A, Regina Elena National Cancer Institute, Rome, Italy · Division of Hematology, Department of Biotecnologie Cellulari ed Ematologia, Sapienza, University of Rome, Rome, Italy · Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA · Department of Microbiology & Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, USA

Open access

No

Article type

Research Article

Broad categories

(BLS) Biochemistry (BLS) Biology - Cancer (BLS) Biology - Cellular (BLS) Genetics

Citation lifecycle

How this paper is being cited

Pre-retraction

124

Same day

0

Post-retraction

4

% post-retraction

3.1%

~9.8 citations/yr before retraction · ~1.8 citations/yr after

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