All studies
Oncology · Registry + Claims · US

Petito 2020

Colorectal cancer, Pancreatic cancer

PPSuperiorityAcademia, Industry, Government2/5 disclosures
Comparisons
2
In the analysis
1
1 withheld
Target trials
2
Emulations reported
2
3 treatments

Comparisons

2 shown
Randomized trialEmulation
Outcome & target trialTrial vs emulationOn a shared scaleAgreement
Overall survival
vs NCIC CTG PA.3·HR·Efficacy
0.960.74–1.24
1.030.96–1.09
overlapPartial alignment0.52 SE apart
Overall survival
vs QUASAR·HR·Efficacy
1.020.70–1.48
1.010.97–1.05
not pooled

Design and methods

Estimand
PP
Design hypothesis
Superiority
Matching / weighting
IPTW
Analysis method
Cox PH
Missing data
LOCF, Complete case
Covariates adjusted
25
DAG
No
QBA
No

Data and sample

Data type
Registry + Claims
Data sources
1
Geography
US
Eligible sample
9549
Treated
185
Control
6150
Emulations
2
Treatments compared
3

Transparency

2/5
Protocol
No pre-registration
Preprint
No preprint
Data availability
Unavailable
Code availability
Unavailable
Conflicts of interest
Declared: Industry
COI institutions
Sanofi Pasteur
Funding
Declared: Public, Research Institute, NGO
Funders
US National Cancer Institute, Patient-Centered Outcomes Research Institute, California Department of Public Health, Centers for Disease Control and Prevention

The 0-5 count records which disclosures are present. It is not a quality score: a data link does not establish that the data are reusable.

Provenance

Review key
2020_Petito_ColorectalPancreaticCancer
DOI
https://doi.org/10.1001/jamanetworkopen.2020.0452
Affiliations
Harvard T.H. Chan School of Public Health, Brown University, Feinberg School of Medicine-Northwestern University, Massachusetts General Hospital, Harvard Medical School, National Cancer Institute, RTI Health Solutions
Sector
Academia, Industry, Government
Target trials (study level)
QUASAR
Registration
ISRCTN82375386