All studies
Cardiology · Registry · Sweden

Szummer 2020

Acute coronary syndrome

ITTSuperiorityAcademia2/5 disclosures
Comparisons
4
In the analysis
4
all comparisons pooled
Target trials
1
Emulations reported
1
2 treatments

Comparisons

4 shown
Randomized trialEmulation
Outcome & target trialTrial vs emulationOn a shared scaleAgreement
(readmission for) major bleeding
vs PLATO·HR·Efficacy
1.040.95–1.13
1.481.25–1.76
no overlapMajor deviation3.60 SE apart
CV Death, MI, Stroke
vs PLATO·HR·Efficacy
0.840.77–0.92
0.970.88–1.06
overlap2.19 SE apart
Myocardial infarction
vs PLATO·HR·Efficacy
0.840.75–0.95
0.800.70–0.92
overlap-0.53 SE apart
Stroke
vs PLATO·HR·Efficacy
1.170.91–1.52
0.720.56–0.93
overlap-2.64 SE apart

Design and methods

Estimand
ITT
Design hypothesis
Superiority
Matching / weighting
IPTW
Analysis method
Cox PH
Missing data
Multiple imputation
Covariates adjusted
35
DAG
No
QBA
No

Data and sample

Data type
Registry
Data sources
1
Geography
Sweden
Eligible sample
14005
Treated
8421
Control
5670
Emulations
1
Treatments compared
2

Transparency

2/5
Protocol
No pre-registration
Preprint
No preprint
Data availability
Unavailable
Code availability
Unavailable
Conflicts of interest
Declared: Industry
COI institutions
AstraZeneca, Sanofi-Aventis, BMS, Eli-Lilly, MSD, Boeringer-Ingelheim, Novartis, Bayer, Merck
Funding
Declared: Public, professional society, NGO
Funders
Stockholm County Council, Swedish Medical Association (Svenska Läkarsällskapet), Swedish Heart Association (Svenska Hjärtförbundet), Swedish Heart and Lung Foundation

The 0-5 count records which disclosures are present. It is not a quality score: a data link does not establish that the data are reusable.

Provenance

Review key
2020_Szummer_AcuteCoronarySyndrome
DOI
https://doi.org/10.1161/circulationaha.120.050645
Affiliations
Karolinska Institutet, Stanford University School of Medicine, Linköping University, Lund University, Uppsala University, University of Gothenburg, Sahlgrenska University Hospital
Sector
Academia
Target trials (study level)
PLATO
Registration
NCT00391872